Research advances on thymosin β4 in promoting wound healing / 中华烧伤杂志

With the aging of population and the development of social economy, the incidence of chronic wounds is increasing day by day, while the incidence of burns and trauma remains at a high level, making wound repair an increasingly concerned area in clinical practice. Thymosin β4 is a naturally occurring small molecule protein in vivo, which is widely distributed in a variety of body fluids and cells, especially in platelets. Thymosin β4 has biological activities of promoting angiogenesis, anti-inflammation, anti-apoptosis, and anti-fibrosis, and has many important functions in wound repair. Thymosin β4 has been observed to promote the healing of various wounds, such as burns, diabetic ulcers, pressure ulcers. This paper will review the molecular structure, mechanism of wound healing promotion, pharmacokinetics, and clinical application of thymosin β4, aiming to introduce its potential in wound treatment and the shortcomings of current researches.

Research advances on signaling pathways affecting sweat gland development and their involvement in the reconstitution of sweat adenoid cells in vitro / 中华烧伤杂志

The damage of sweat glands in patients with extensive deep burns results in the loss of thermoregulation, which seriously affects the quality of life of patients. At present, there are many researches on the repair of sweat gland function, but the mechanism of human sweat gland development has not been fully clarified. More and more studies have shown that the cascaded pathways of Wnt/β-catenin, ecto- dysplasin A/ectodysplasin A receptor/nuclear factor-κB, sonic hedgehog, and forkhead box transcription factor jointly affect the development of sweat glands, and it has been reported that the cascaded signaling pathways can be used to achieve the reconstruction of sweat adenoid cells in vitro. This article reviews the signaling pathways that affect the development of sweat glands and their involvement in the reconstruction of sweat adenoid cells in vitro.

Clinical application of located subcutaneous jugular vein inserted central catheter in cancer patients / 中华护理杂志

Objective To explore the clinical application of located subcutaneous jugular vein inserted central catheter (LSJICC) in patients with malignant tumors. Methods The patients with malignant tumors treated in our hospital from January 2013 to December 2016 were enrolled and divided into the experimental group and the con-trol group according to the order of catheterization. Two groups were catheterized with LSJICC and PICC,respective-ly. Indwelling time of the catheter and incidence of complications were compared between two groups. The Kaplan-Meier survival curve was used to reflect the occurrence of CRBSIs in both groups,and the log-rank test was used to compare the results. The pathogenicity distribution of CRBSIs was analyzed and multivariate Cox regression analysis was performed. Results A total of 450 patients were enrolled in this study,including 228 patients in the experimental group and 222 patients in the control group. The average indwelling time of the catheter in the ex-perimental group(212.24 ± 79.80) was significantly longer than that in the control group(79.73 ± 34.86). The in-cidence of complications in the experimental group was significantly lower than that in the control group. The CRBSIs Kaplan-Meier survival curve of the experimental group was significantly better than that of the control group(P<0.01). The top three pathogens of CRBSIs were staphylococcus aureus,candida and klebsiella pneumoniae. Multivariate Cox regression analysis of CRBSIs showed that the site of catheter placement,the method of catheter placement and the type of tumor were independent risk factors for infection. Conclusion The incidence of compli-cations are significantly reduced with LSJICC,and indwelling time of the catheter is significantly prolonged,which is more in line with the actual needs of cancer patients undergoing chemotherapy.

Optimization of antibiotics in combination / 中华烧伤杂志

<p><b>OBJECTIVE</b>To evaluate the antibacterial activity of Ciprofloxacin, Amikacin in combination with beta-lactams against Pseudomonas aeruginosa strains in vitro, to optimize treatment regime for antibiotics on the basis of pharmacokinetics (PK)/pharmacodynamics (PD) and drug sensitivity tests. Methods With checkerboard titration method, the minimal inhibitory concentrations (MIC) of a combination of antibiotics in different concentrations for 33 clinically isolated Pseudomonas aeruginosa strains were determined by broth dilution. Fractional inhibitory concentrations (FIC) were calculated for judging synergic effect of antibiotics.</p><p><b>RESULTS</b>The combination of Amikacin and Ceftazidime showed synergic effects (accounting for 57.6%). The combinations of Ciprofloxacin with Ceftazidime, Cefepime, Imipenem/Cilastatin, Meropenem showed synergic or additive effect. In the study with PK/PD, C(max)/MIC was the principal parameters for evaluation of aminoglycoside and fluoroquinolone antibiotics, while T > MIC was the principal parameter to be used to evaluate beta-lactams antibiotics.</p><p><b>CONCLUSION</b>When antibiotics are used in combination, MICs can be reduced significantly and antibacterial activities are enhanced remarkably. The combination of antibiotics results mainly in synergic or additive effect, and no inhibitory effect is observed. PK/PD analysis plays an important role in planning optimal combination regime to raise clinical efficacy.</p>

The efficacy of biological dressing containing calcium and magnesium on the management of hydrofluoric acid burns / 中华烧伤杂志

<p><b>OBJECTIVE</b>To observe the efficacy of biological dressing containing calcium and magnesia (sheep dermis absorbing calcium and magnesia and cross-link with glutaraldehyde) on the management of hydrofluoric acid burns in rats and patients.</p><p><b>METHODS</b>Wistar rats were randomly divided into A ( n = 24, normal control, with isotonic saline dressing after burns), B ( n = 32, with isotonic saline dressing treatment after hydrofluoric acid burns), C ( n = 32, with wet-dressing treatment after hydrofluoric acid burns), and D ( n = 32, with biological dressing treatment after hydrofluoric acid burns) groups. The rats in the latter 3 groups were inflicted with 3 cm x 3 cm TBSA full-thickness burns, and mortality, concentration of blood calcium , histopathological observation were carried out at 4,8,24 and 72 postburn hours (PBH), with 8 rats at each time-points. In addition, 46 patients with hydrofluoric acid burns were divided into E (with wet-dressing treatment) and F (with biological dressing treatment) groups to compare the curative effect.</p><p><b>RESULTS</b>The mortality in A,B,C,D groups were 0,31.2% ,15. 6% ,6. 2% , respectively. The wound in B group was deepened gradually after burns, but that in D group was slighter when compared with that in C group. The concentration of blood calcium in A group was higher than that in B, C and D groups at each time-points, and that in D groups was higher than that in B and C groups. The concentration of blood calcium in D group at 8 and 24 PBH were [(2.215 +/-0.008) ,(2.216 +/-0.008) mmol/L], which were obviously higher than those in B [(1.813 +/-0.017),(1.912 +/-0.013)mmol/L l] and C [(2.015 +/-0.006), (2.018 +/-0. 010)mmol/L] groups, (P <0. 01). The clinical outcome in E group was much better than that in F group.</p><p><b>CONCLUSION</b>Biological dressing containing calcium and magnesium can be applied in the emergency management and following treatment after hydrofluoric acid burns.</p>

Coping and mediating effect between parents' rearing attitude and problem behavior of pre-school children / 中华预防医学杂志

<p><b>OBJECTIVE</b>To explore the children's coping strategies and their mediation effects between parents' rearing and children's problem behavior.</p><p><b>METHODS</b>Using Parents' Childrearing Question-naire, Child Behavioral Checklist of Achenbach and the method of story-context evaluation, a sample of 204 children was tested.</p><p><b>RESULTS</b>Contexts effects in coping were found. The mean of proportion scores of problem approach coping of 4-year and 5-year old children (0.42 +/- 0.28, 0.41 +/- 0.30) was significantly more than that of 3-year-old children (0.21 +/- 0.19). The results also showed that problem approach coping could negatively forecast the children's externalizing and internalizing problem behaviors. Coping could partly moderate the relation between parents' childrearing attitude and child problems behavior.</p><p><b>CONCLUSION</b>With age increasing, children's coping strategies become more and more mature. Problem approach coping is a positive coping method for preschoolers, and might prevent their problem behaviors effectively.</p>

Stress and mental health of farmer-workers / 中华劳动卫生职业病杂志

<p><b>OBJECTIVE</b>To study the farmer-workers'stress, their mental health and the effect of stress on mental health.</p><p><b>METHODS</b>The Stressors Scale and SCL-90 were used for the test in a sample of 500 farmer-workers.</p><p><b>RESULTS</b>The primary mental stressors of the farmer-workers were economic burden, protection of their rights and interests and working condition & load. There was difference in the degree of stress among the age groups and the groups of the degree of education. Farmer-workers under 29 years old experienced the most mental stress, those between 30 years old and 39 years old experienced less, and those above 40 years old experienced the least mental stress. In the Interpersonal Relationship Stress Scale, the scores of those with senior middle school education or above were higher than those with junior middle school education or even illiterate. But the scores in all other stress scale and the total stress scores were different: the scores of those illiterate and those with senior middle school education or above, were higher than those with junior middle school education or lower. The mental health status of the farmer-workers was lower than the norm. The farmer-workers with at least one positive symptom factor accounted for 12.30% with the detectable rate of the factors of SCL-90 ranging from 1.9% to 6.5%. Most stressors could predict the mental health of the farmer-workers positively and remarkably.</p><p><b>CONCLUSION</b>Some farmer-workers have mental disorders. Mental stress plays an important role in the mental health of the farmer-workers.</p>